DHPCC-9 | Pim inhibitor | Probechem Biochemicals

Chemical Structure : DHPCC-9

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DHPCC-9 (DHPCC9)

货号: PC-38739Not For Human Use, Lab Use Only.

DHPCC-9 is a selective Pim kinase inhibitor, inhibits Pim-1-dependent survival of cytokine-deprived myeloid cells (IC50=4-6 uM).

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100 mg		Get quote

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生物&药学活性

DHPCC-9 is a selective Pim kinase inhibitor, inhibits Pim-1-dependent survival of cytokine-deprived myeloid cells (IC50=4-6 uM).
DHPCC-9 represses intracellular phosphorylation of Bad by Pim kinases.
DHPCC-9 decreases migration of prostate cancer cells without affecting Pim protein levels or cell viability, also reduces migration of squamocellular carcinoma cells.
DHPCC-9 drastically decreases tumor volumes as well as the metastatic capacity in prostate cancer xenografts.

物理化学性质&存储条件

分子量	234.258
分子式	C15H10N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde

参考文献

1. Santio NM, et al. Mol Cancer. 2010 Oct 19;9:279.

DHPCC-9 (DHPCC9)

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物理化学性质&存储条件

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DHPCC-9 (DHPCC9)

生物&药学活性

物理化学性质&存储条件

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