DHODH inhibitor GSK983 | DHODH inhibitor | Probechem Biochemicals

Chemical Structure : DHODH inhibitor GSK983

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DHODH inhibitor GSK983 (GSK-983)

货号: PC-72538Not For Human Use, Lab Use Only.

GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM.

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生物&药学活性

GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM.
GSK983 inhibits the growth of cell lines immortalized by HTLV-1, EBV, HPV, SV40 and Ad-5, with EC50 values in the range of 10-40 nM.
GSK983 induces either apoptosis or cytostasis at concentrations over 20 nM.
GSK983 also inhibits cell lines immortalized by non-viral mechanisms, but has little effect on primary cells.
GSK983 inhibited K562 cell growth with an IC50 of 21 nM, GSK983 treatment caused an accumulation of K562 cells in S phase.
GSK983 inhibits DHODH to block virus replication and cell proliferation.
GSK983 displayed a marked inhibitory effect on the proliferation of neuroblastoma cell lines with IC50 values from nanomoles to low micromoles.

物理化学性质&存储条件

分子量	325.796
分子式	C18H16ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide

参考文献

1. Qi Liu, et al. Cell Chem Biol. 2020 Jun 18;27(6):668-677.e9.

2. Robert Harvey, et al. Antiviral Res. 2009 Apr;82(1):1-11.

3. Yajie Yu, et al. Cell Death Dis. 2021 Aug 30;12(9):821.

4. Richard M Deans, et al. Nat Chem Biol. 2016 May;12(5):361-6.

DHODH inhibitor GSK983 (GSK-983)

生物&药学活性

物理化学性质&存储条件

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DHODH inhibitor GSK983 (GSK-983)

生物&药学活性

物理化学性质&存储条件

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