DHMEQ | NF-κB inhibitor | Probechem Biochemicals

Chemical Structure : DHMEQ

CAS No.: 287194-40-5

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DHMEQ (Dehydroxymethylepoxyquinomicin, (-)-DHMEQ)

货号: PC-47044Not For Human Use, Lab Use Only.

DHMEQ (dehydroxymethylepoxyquinomicin) is an NF-κB inhibitor, inhibits TNF-α-induced activation of NF-κB, and inhibits the TNF-α-induced nuclear accumulation of p65, a component of NF-κB.

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25 mg	￥4580	In stock
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生物&药学活性

DHMEQ (dehydroxymethylepoxyquinomicin) is an NF-κB inhibitor, inhibits TNF-α-induced activation of NF-κB, and inhibits the TNF-α-induced nuclear accumulation of p65, a component of NF-κB.
DHMEQ also inhibited TNF-α-induced nuclear transport of green fluorescent protein-tagged p65.
DHMEQ was effective in suppressing rheumatoid arthritis in an in vivo model.
DHMEQ completely inhibited NFkappaB DNA binding activity in JCA-1 cells.
DHMEQ significantly inhibited pre-established JCA-1 s.c. tumor growth in nude mice without any side effects.

物理化学性质&存储条件

分子量	261.23
分子式	C13H11NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide

参考文献

1. Ariga A, et al. J Biol Chem. 2002 Jul 5;277(27):24625-30.

2. Chaicharoenpong C, et al. Bioorg Med Chem. 2002 Dec;10(12):3933-9.

3. Kikuchi E, et al. Cancer Res. 2003 Jan 1;63(1):107-10.

DHMEQ (Dehydroxymethylepoxyquinomicin, (-)-DHMEQ)

生物&药学活性

物理化学性质&存储条件

参考文献

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DHMEQ (Dehydroxymethylepoxyquinomicin, (-)-DHMEQ)

生物&药学活性

物理化学性质&存储条件

参考文献

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