DHC-156 | Brachyury inhibitor | Probechem Biochemicals

Chemical Structure : DHC-156

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DHC-156 (DHC156)

货号: PC-21752Not For Human Use, Lab Use Only.

DHC-156 is a covalent small molecule inhibitor of oncogenic transcription factor brachyury, selectively binds to brachyury, DHC-156 is potent brachyury downmodulator with DC50 of 4.1 uM.

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生物&药学活性

DHC-156 is a covalent small molecule inhibitor of oncogenic transcription factor brachyury, selectively binds to brachyury, DHC-156 is potent brachyury downmodulator with DC50 of 4.1 uM.
DHC-156 is a chemical analog of afatinib that lacks kinase inhibition activity, whereas afatinib is highly reactive with multiple kinases.
DHC-156 (10 uM) significantly decreased the brachyury fluorescent by immunofluorescent staining of brachyury in CH-22 cells.
DHC-156 downmodulates brachyury post-translationally, displays loss of brachyury phenotyp, results in an irreversible impairment of chordoma tumor cell growth.

物理化学性质&存储条件

分子量	492.47
分子式	C24H24F4N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(dimethylamino)-N-(1-((4-fluoro-3-(2,2,2-trifluoroethoxy)phenyl)amino)-6-methoxyisoquinolin-7-yl)but-2-enamide

参考文献

1. Chase DH, et al. Angew Chem Int Ed Engl. 2024 Feb 13:e202316496.

DHC-156 (DHC156)

生物&药学活性

物理化学性质&存储条件

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DHC-156 (DHC156)

生物&药学活性

物理化学性质&存储条件

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