DGY-06-116 | SRC inhibitor | Probechem Biochemicals

Chemical Structure : DGY-06-116

CAS No.: 2556836-50-9

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DGY-06-116 (SRC inhibitor 15a)

货号: PC-72224Not For Human Use, Lab Use Only.

DGY-06-116 (SRC inhibitor 15a) is a potent, selective, covalent Src inhibitor (biochemical IC50=3 nM) that taregrs a P-Loop cysteine (Cys277).

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5580	In stock
250 mg		Get quote

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生物&药学活性

DGY-06-116 (SRC inhibitor 15a) is a potent, selective, covalent Src inhibitor (biochemical IC50=3 nM) that taregrs a P-Loop cysteine (Cys277).
BTK, ABL, and most SFK family members such as HCK, BLK, LCK, and YES1 were the main off-targets as confirmed with low nanomolar biochemical IC50s.
DGY-06-116 demonstrated potent antiproliferative effects in lung and breast cancer cell lines (H1957 GI50=0.3 uM).
DGY-06-116 inhibited p-SRCY416 signaling in both H1975 and HCC827 cells at 1 uM.
DGY-06-116 inhibited p-SRCY416 at 2 and 4 h postdosing in spleen tissue samples from C57B6 mice.

物理化学性质&存储条件

分子量	597.12
分子式	C32H33ClN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-Acrylamidophenyl)amino)-N-(2-chloro-6-methylphenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

参考文献

1. Guangyan Du, et al. J Med Chem. 2020 Feb 27;63(4):1624-1641.

2. Gurbani D, et al. Front Mol Biosci. 2020 May 19;7:81.

DGY-06-116 (SRC inhibitor 15a)

生物&药学活性

物理化学性质&存储条件

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DGY-06-116 (SRC inhibitor 15a)

生物&药学活性

物理化学性质&存储条件

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