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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Diglyceride Acyltransferase (DGAT)-DGAT2 inhibitor 2
DGAT2 inhibitor 2

Chemical Structure : DGAT2 inhibitor 2

CAS No.: 2337332-89-3

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DGAT2 inhibitor 2

货号: PC-63472Not For Human Use, Lab Use Only.

DGAT2 inhibitor 2 is a novel potent, selective DGAT2 inhibitor with IC50 of 6 nM (hDGAT2), shows no significant activity for DGAT1 (IC50>20 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DGAT2 inhibitor 2 is a novel potent, selective DGAT2 inhibitor with IC50 of 6 nM (hDGAT2), shows no significant activity for DGAT1 (IC50>20 uM).
    DGAT2 inhibitor 2 shows effective reduction of newly synthesized TG appearing in plasma in acute rodent model.

    物理化学性质&存储条件

    分子量 496.981
    分子式 C26H22ClFN2O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indole-6-carboxamide

    参考文献

    1. McLaren DG, et al. Cell Metab. 2018 Apr 20. pii: S1550-4131(18)30245-6.

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