DGAT1-IN-4 |CAS:942999-61-3 Probechem Biochemicals

Chemical Structure : DGAT1-IN-4

CAS No.: 942999-61-3

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DGAT1-IN-4 (DGAT-1 inhibitor 4)

货号: PC-45835Not For Human Use, Lab Use Only.

DGAT1-IN-4 is a potent, selective, and orally efficacious inhibitor of DGAT-1 with IC50 of 15 nM and 9 nM for hDGAT-1 and mDGAT-1, respectively.

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10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DGAT1-IN-4 is a potent, selective, and orally efficacious inhibitor of DGAT-1 with IC50 of 15 nM and 9 nM for hDGAT-1 and mDGAT-1, respectively.
DGAT1-IN-4 shows no significant activity for ACAT-1 (IC50=5.2 uM).
DGAT1-IN-4 shows effectivity in both intestinal and adipose tissue, reduces body weight or body weight gain following oral administration in both mouse and rat models of dietary-induced obesity.

物理化学性质&存储条件

分子量	420.5041
分子式	C24H28N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Bicyclo[2.2.2]octane-1-acetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-

参考文献

1. Birch AM, et al. J Med Chem. 2009 Mar 26;52(6):1558-68.

DGAT1-IN-4 (DGAT-1 inhibitor 4)

生物&药学活性

物理化学性质&存储条件

参考文献

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DGAT1-IN-4 (DGAT-1 inhibitor 4)

生物&药学活性

物理化学性质&存储条件

参考文献

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