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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-DG051
DG051

Chemical Structure : DG051

CAS No.: 929915-58-2

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DG051 (DG-051;DG 051)

货号: PC-42712Not For Human Use, Lab Use Only.

DG051 (DG-051) is a potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3880 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DG051 (DG-051) is a potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis.
DG051 dispalys selectivity over a panel of more than 50 targets including aminopeptidases, hERG, GPCRs.
DG051 has high aqueous solubility (>30 mg/mL) and high oral bioavailability.

物理化学性质&存储条件

分子量 426.3335
分子式 C21H25Cl2NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 325 mg/mL
Chemical Name/SMILES

1-Pyrrolidinebutanoic acid, 2-[[4-(4-chlorophenoxy)phenoxy]methyl]-, hydrochloride (1:1), (2S)-

参考文献

1. Sandanayaka V, et al. J Med Chem. 2010 Jan 28;53(2):573-85.

2. Enache LA, et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6275-9.

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