DG-041 (DG041) | EP3 antagonist | Probechem Biochemicals

Chemical Structure : DG041

CAS No.: 861238-35-9

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DG041 (DG-041)

货号: PC-27720Not For Human Use, Lab Use Only.

DG-041 (DG041) is a potent and selective prostanoid EP3 receptor antagonist with IC50 of 4.6 nM and 8.1 nM in binding and FLIPR assay, respectively.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

DG-041 (DG041) is a potent and selective prostanoid EP3 receptor antagonist with IC50 of 4.6 nM and 8.1 nM in binding and FLIPR assay, respectively.
DG-041 antagonized the effects of sulprostone on platelet function.
DG-041 potentiated the protective effects of PGE(2) on platelet aggregation by inhibiting the pro-aggregatory effect via EP3 stimulation.
DG041 (30 mg/kg) enhanced bladder capacity, inhibited the responses to GR63799X supporting the in vivo activity.

物理化学性质&存储条件

分子量	592.30
分子式	C23H15Cl4FN2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-dichlorothiophene-5-sulfonic acid, 3-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]acryloylamide

参考文献

1. Singh J, et al. J Med Chem. 2010 Jan 14;53(1):18-36.

2. Heptinstall S, et al. Platelets. 2008 Dec;19(8):605-13.

3. Jugus MJ, et al. Br J Pharmacol. 2009 Sep;158(1):372-81.

DG041 (DG-041)

生物&药学活性

物理化学性质&存储条件

参考文献

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DG041 (DG-041)

生物&药学活性

物理化学性质&存储条件

参考文献

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