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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-DG013A
DG013A

Chemical Structure : DG013A

CAS No.: 2007955-07-7

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DG013A (DG 013A)

货号: PC-72271Not For Human Use, Lab Use Only.

DG013A (DG 013A) is tripeptide mimetic chemical probe (inhibitor) of ERAP1 with IC50 of 0.19 uM, 15-fold selectivity over ERAP2, potently inhibits aminopeptidase N (APN) with IC50 of 3.7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DG013A (DG 013A) is tripeptide mimetic chemical probe (inhibitor) of ERAP1 with IC50 of 0.19 uM, 15-fold selectivity over ERAP2, potently inhibits aminopeptidase N (APN) with IC50 of 3.7 nM.

物理化学性质&存储条件

分子量 512.591
分子式 C27H37N4O4P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((S)-2-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-4-methylpentyl)((R)-1-amino-3-phenylpropyl)phosphinic acid

参考文献

1. Birgit Wilding, et al. Bioorg Med Chem Lett. 2021 Jun 15;42:128050.

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