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首页-小分子抑制剂&激动剂-Others-Other Targets-DFP00173
DFP00173

Chemical Structure : DFP00173

CAS No.: 672286-03-2

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DFP00173 (DFP-00173)

货号: PC-36121Not For Human Use, Lab Use Only.

DFP00173 (DFP 00173) is a potent and selective aquaporin-3 (AQP3) inhibitor with IC50 of 0.9-1.4 uM for mouse and human AQP3, with low efficacy toward mouse AQP7 and AQP9.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DFP00173 (DFP 00173) is a potent and selective aquaporin-3 (AQP3) inhibitor with IC50 of 0.9-1.4 uM for mouse and human AQP3, with low efficacy toward mouse AQP7 and AQP9.
DFP00173 inhibits glycerol permeability in erythrocytes with IC50 of 0.2 uM, agreed well with the inhibition of water permeability in CHO cells.

物理化学性质&存储条件

分子量 332.155
分子式 C11H7Cl2N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea

参考文献

1. Sonntag Y, et al. J Biol Chem. 2019 Mar 11. pii: jbc.RA118.006083. doi: 10.1074/jbc.RA118.006083.

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