DFP-4AP

Chemical Structure : DFP-4AP

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货号: PC-28492Not For Human Use, Lab Use Only.

DFP-4AP is a small molecule inhibitor of HIV-1 accessory protein Nef, inhibits the Nef-Hck complex via the Hck kinase domain, inhibits Nef-induced Hck activation (IC50=5.1 uM) and HIV-1 replication (IC50=6 uM).

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生物&药学活性

DFP-4AP is a small molecule inhibitor of HIV-1 accessory protein Nef, inhibits the Nef-Hck complex via the Hck kinase domain, inhibits Nef-induced Hck activation (IC50=5.1 uM) and HIV-1 replication (IC50=6 uM).

物理化学性质&存储条件

分子量	345.40
分子式	C21H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)amino]-1-propanol

参考文献

1. Ryan P Staudt, et al. J Biol Chem. 2020 Oct 30;295(44):15158-15171.

2. Lori Emert-Sedlak, et al. ACS Chem Biol. 2009 Nov 20;4(11):939-47.

DFP-4AP

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物理化学性质&存储条件

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DFP-4AP

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物理化学性质&存储条件

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