DFMO (MDL71782, Eflornithine) | Ornithine decarboxylase inhibitor

Chemical Structure : DFMO

CAS No.: 70052-12-9

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DFMO (MDL71782, RMI71782, α-difluoromethylornithine, Eflornithine)

货号: PC-36049Not For Human Use, Lab Use Only.

DFMO (MDL71782, RMI71782, α-difluoromethylornithine, Eflornithine) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.

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500 mg	￥880	In stock
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生物&药学活性

DFMO (MDL71782, RMI71782, α-difluoromethylornithine, Eflornithine) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.
DFMO displays antiapoptotic, antiangiogenic and antiparasitic activity, synergistically reduces cell viability in NB cells when combined with AMXT-1501, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.

物理化学性质&存储条件

分子量	182.171
分子式	C6H12F2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,5-diamino-2-(difluoromethyl)pentanoic acid

参考文献

1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.

2. Wu Y, et al. Biochem J. 2012 Mar 15;442(3):693-701.

3. Carrillo C, et al. Biochem Biophys Res Commun. 2000 Dec 20;279(2):663-8.

DFMO (MDL71782, RMI71782, α-difluoromethylornithine, Eflornithine)

生物&药学活性

物理化学性质&存储条件

参考文献

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DFMO (MDL71782, RMI71782, α-difluoromethylornithine, Eflornithine)

生物&药学活性

物理化学性质&存储条件

参考文献

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