DETQ

Chemical Structure : DETQ

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货号: PC-60735Not For Human Use, Lab Use Only.

DETQ is a novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM.

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生物&药学活性

DETQ is a novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM.
DETQ induces a 21-fold leftward shift in the cAMP response to dopamine in HEK293 cells, 30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor.
DETQ robustly (∼10-fold) increases locomotor activity in habituated hD1 mice (3-20 mg/kg), also acts synergistically with L-DOPA to reverse the strong hypokinesia caused by reserpine.

物理化学性质&存储条件

分子量	422.346
分子式	C22H25Cl2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

参考文献

1. Svensson KA, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128.

2. Bruns RF, et al. Neuropharmacology. 2018 Jan;128:351-365.

DETQ

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物理化学性质&存储条件

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DETQ

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