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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Discoidin Domain Receptor (DDR)-DDR2-IN-5
DDR2-IN-5

Chemical Structure : DDR2-IN-5

CAS No.: 1796592-06-7

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DDR2-IN-5

货号: PC-62395Not For Human Use, Lab Use Only.

DDR2-IN-5 is a potent, dual DDR2/SRC inhibitor with IC50 of 56/12 nM, potently suppresses DDR2 mutated cell lines HCC-366 and NCI-H2286 with IC50 of 0.44 uM and 0.29 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DDR2-IN-5 is a potent, dual DDR2/SRC inhibitor with IC50 of 56/12 nM, potently suppresses DDR2 mutated cell lines HCC-366 and NCI-H2286 with IC50 of 0.44 uM and 0.29 uM.

    物理化学性质&存储条件

    分子量 605.666
    分子式 C32H34F3N7O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-5-(1-methyl-1H-pyrazol-4-yl)nicotinamide

    参考文献

    1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96.

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