DDR1 inhibitor 2.45 |CAS:2125676-13-1 Probechem Biochemicals

Chemical Structure : DDR1 inhibitor 2.45

CAS No.: 2125676-13-1

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DDR1 inhibitor 2.45 (Compound 2.45)

货号: PC-35802Not For Human Use, Lab Use Only.

DDR1 inhibitor 2.45 (Compound 2.45) is a novel potent, selective, bioavailable Discoidin Domain Receptor 1 (DDR1) inhibitor with IC50 of 29 nM, displays 64-fold selectivity over DDR2 in biochemical assays.

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生物&药学活性

DDR1 inhibitor 2.45 (Compound 2.45) is a novel potent, selective, bioavailable Discoidin Domain Receptor 1 (DDR1) inhibitor with IC50 of 29 nM, displays 64-fold selectivity over DDR2 in biochemical assays.
DDR1 inhibitor 2.45 also possesses excellent kinome selectivity against a kinase panel of 468 kinases.
DDR1 inhibitor 2.45 inhibits DDR1 phosphorylation (70% inhibition at 1 uM in HT1080 cells overexpressing DDR1) and recruitment of SHC1 in vitro, and modulates phenotype of collagen stimulated renal epithelial cells.
DDR1 inhibitor 2.45 preserves renal function and reduces tissue damage in Col4a3−/− mice (the preclinical mouse model of Alport syndrome).

物理化学性质&存储条件

分子量	565.351
分子式	C23H20BrF3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-bromo-2-oxo-1'-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)spiro[indoline-3,4'-piperidin]-1-yl)-N-(2,2,2-trifluoroethyl)acetamide

参考文献

1. Richter H, et al. ACS Chem Biol. 2018 Nov 19. doi: 10.1021/acschembio.8b00866.

DDR1 inhibitor 2.45 (Compound 2.45)

生物&药学活性

物理化学性质&存储条件

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DDR1 inhibitor 2.45 (Compound 2.45)

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物理化学性质&存储条件

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