DDR-TRK-1 | DDR1 inhibitor | Probechem Biochemicals

Chemical Structure : DDR-TRK-1

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DDR-TRK-1 (DDR1 inhibitor 6j)

货号: PC-35847Not For Human Use, Lab Use Only.

DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM, also potently inhibits TRK family with IC50 of 18-100 nM.

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生物&药学活性

DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM, also potently inhibits TRK family with IC50 of 18-100 nM.
DDR-TRK-1 inhibits colony formation and migration of Panc-1 pancreatic cancer cells.
In cellular and mouse models of lung fibrosis, DDR-TRK-1 inhibits signaling, expression of fibrotic markers and fibrotic features such as hydroxproline expression.
DDR-TRK-1 is selective in KINOMEscan at 1 uM,t he closest off target is CDK11 (370 nM).

物理化学性质&存储条件

分子量	492.506
分子式	C26H23F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

参考文献

1. Wang Z, et al. J Med Chem. 2016 Jun 23;59(12):5911-6.

2. PCT Int. Appl. (2016), WO 2016064970 A1 20160428.

DDR-TRK-1 (DDR1 inhibitor 6j)

生物&药学活性

物理化学性质&存储条件

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DDR-TRK-1 (DDR1 inhibitor 6j)

生物&药学活性

物理化学性质&存储条件

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