DDO-8926 | BET inhibitor | Probechem Biochemicals

Chemical Structure : DDO-8926

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DDO-8926 (DDO 8926)

货号: PC-20948Not For Human Use, Lab Use Only.

DDO-8926 is a potent selective inhibitor of bromodomain and extra-terminal (BET) proteins with Ki values of 15 nM (BRD4 BD1) and 9.5 nM (BRD4 BD2).

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1 g		Get quote

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生物&药学活性

DDO-8926 is a potent selective inhibitor of bromodomain and extra-terminal (BET) proteins with Ki values of 15 nM (BRD4 BD1) and 9.5 nM (BRD4 BD2).
DDO-8926 showed excellent selectivity over the non-BET bromodomains at 1 uM by the BROMOscan (Eurofins DiscoverX).
DDO-8926 (30 mg/kg, ip) attenuates NP hypersensitivity, regulates genes involved in the generation and transfer of action potentials and inflammatory response.
DDO-8926 reduces microglial and neuronal activation in the spinal cord after SNI and has no effect on astrocytes, alleviates inflammation and affects the expression of ion channels and the Na+/K+ ATPase pump in the spinal cord at 15 dpo after SNI.

物理化学性质&存储条件

分子量	428.49
分子式	C20H21FN6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CCS(=O)(NC1=CC(C2=C(C)N(C)N=C2C)=C(F)C(C3=C4C(N=CN4)=NC=C3)=C1)=O

参考文献

1. Xuetao Chen, et al. J Med Chem. 2023 Jul 13;66(13):8725-8744.

DDO-8926 (DDO 8926)

生物&药学活性

物理化学性质&存储条件

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DDO-8926 (DDO 8926)

生物&药学活性

物理化学性质&存储条件

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