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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-DDO-7263
DDO-7263

Chemical Structure : DDO-7263

CAS No.: 2254004-96-9

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DDO-7263 (DDO7263)

货号: PC-22478Not For Human Use, Lab Use Only.

DDO-7263 is a a potent small molecule Nrf2-ARE activator, inhibits NLRP3 inflammasome activationand shows neuroprotective effect, upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome.

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5 mg ￥1480 In stock
10 mg ￥2380 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DDO-7263 is a a potent small molecule Nrf2-ARE activator, inhibits NLRP3 inflammasome activationand shows neuroprotective effect, upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome.
DDO-7263 protects PC12 neurons from H2O2-induced oxidative damage.
DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2.
DDO-7263 significantly inhibited NLRP3 activation, cleaved caspase-1 production and IL-1β protein expression in ATP-LPS-exposed THP-Ms cells.
DDO-7263 improves the behavioral abnormalities induced by MPTP in mice, significantly attenuates chemically induced dopaminergic neuron loss of tyrosine hydroxylase (TH) in the substantia nigra (SN) and striatum of the mouse brain and inhibited the secretion of inflammatory factors.

物理化学性质&存储条件

分子量 273.24
分子式 C14H9F2N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole

参考文献

1. Xu LL, et al. Free Radic Biol Med. 2019 Apr;134:288-303.

2. Dai Z, et al. J Med Chem. 2022 Mar 24;65(6):5029-5043.

3. L.L. Xu, et al. Eur. J. Med. Chem., 157 (2018), pp. 1376-1394

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