DDO-6600 | Hsp90 Covalent inhibitor | Probechem Biochemicals

Chemical Structure : DDO-6600

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DDO-6600 (DDO 6600)

货号: PC-72553Not For Human Use, Lab Use Only.

DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM).

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生物&药学活性

DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM).
DDO-6600 exhibited antiproliferative activities against multiple tumor cells without inhibiting ATPase activity.
DDO-6600 induced the degradation of kinase client proteins in multiple tumor cell lines, promoted apoptosis, and inhibited cell motility.
DDO-6600 exhibits antitumor activity in HCT-116 mouse models.

物理化学性质&存储条件

分子量	428.536
分子式	C26H28N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(3-(3-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazol-4-yl)acryloyl)piperidine-2-carboxamide

参考文献

1. Li Li, et al. Cell Chem Biol. 2021 Oct 21;28(10):1446-1459.e6.

DDO-6600 (DDO 6600)

生物&药学活性

物理化学性质&存储条件

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DDO-6600 (DDO 6600)

生物&药学活性

物理化学性质&存储条件

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