DDO-6079 | CDC37 inhibitor | Probechem Biochemicals

Chemical Structure : DDO-6079

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DDO-6079 (DDO6079)

货号: PC-23505Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

DDO-6079 is a specific, allosteric small-molecule CDC37 inhibitor, binds to an allosteric site on the CDC37 M-terminal domain with ITC Kd of 1.03 uM, inhibits the binding between HSP90-CDC37 and CDC37-kinase.
DDO-6079 simultaneously inhibits HSP90-CDC37 and CDC37-CDK4/6 chaperone comple.
DDO-6079 inhibits the formation of the HSP90-CDC37-CDK4/6 complex in cells in an allosteric manner and selectively inhibits the maturation of multiple oncogenic kinases escape from the heat shock response (HSR).
DDO-6079 exhibits no effects on HSR related protein (HSF-1, HSP70, HSP40 or HSP27).
DDO-6079 shows antiproliferation activity and decreased the thermostability of CDK6 to reverse the resistance of colorectal cancer cells to palbociclib.
DDO-6079 reversed the resistance of CDK6 to palbociclib (a successful CDK4/6 inhibitor) in colorectal cancer cells and exhibited efficacy in vivo.

物理化学性质&存储条件

分子量	340.76
分子式	C18H13ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-2-hydroxy-N-(2-phenoxypyridin-4-yl)benzamide

参考文献

1. Zhang L, et al. Angew Chem Int Ed Engl. 2024 Nov 24:e202413618.

DDO-6079 (DDO6079)

生物&药学活性

物理化学性质&存储条件

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DDO-6079 (DDO6079)

生物&药学活性

物理化学性质&存储条件

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