DDL-920 | GABAA receptor NAM | Probechem Biochemicals

Chemical Structure : DDL-920

CAS No.: 1236105-84-2

加入收藏

DDL-920 (DDL920)

货号: PC-22875Not For Human Use, Lab Use Only.

DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo.

规格	价格	库存
2 mg	￥2880	In stock
5 mg	￥4780	In stock
10 mg	￥7580	In stock
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABAARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo.
DDL-920 ( 1 nM) increases the power of the γ-oscillations, blocks >75% of tonic inhibition of PV+INs with only a negligible effect on their phasic inhibition in vitro.
DDL-920 increases γ-oscillations and improves cognition/memory in a mouse model of Alzheimer's disease (AD).
DDL-920 (10 mg/kg, oral) restored the cognitive/memory impairments of 3- to 4-mo-old AD model mice as measured by their performance in the Barnes maze.

物理化学性质&存储条件

分子量	307.40
分子式	C19H21N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(naphthalen-2-ylmethyl)-4-(piperidin-4-yl)-1H-pyrazol-1-ol

参考文献

1. Wei X, et al. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2400420121.

DDL-920 (DDL920)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DDL-920 (DDL920)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.