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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-DDD1870799
DDD1870799

Chemical Structure : DDD1870799

CAS No.:

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DDD1870799

货号: PC-23957Not For Human Use, Lab Use Only.

DDD1870799 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 2.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DDD1870799 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 2.5 uM.

物理化学性质&存储条件

分子量 354.39
分子式 C19H19FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-fluorophenyl)-1-(3-(6-hydroxy-1H-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl)ethan-1-one

参考文献

1. Pearson LA, et al. Biochem J. 2025 Jan 27:BCJ20240608.

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