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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-DDD1060606
DDD1060606

Chemical Structure : DDD1060606

CAS No.: 1381321-59-0

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DDD1060606 (DDD 1060606)

货号: PC-23956Not For Human Use, Lab Use Only.

DDD1060606 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DDD1060606 is a small molecule inhibitor of HsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM.

    物理化学性质&存储条件

    分子量 326.42
    分子式 C17H18N4OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(1H-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl)-2-(thiophen-3-yl)ethan-1-one

    参考文献

    1. Pearson LA, et al. Biochem J. 2025 Feb 17;482(4):BCJ20240608.

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