DDD1060606

Chemical Structure : DDD1060606

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货号: PC-23956Not For Human Use, Lab Use Only.

DDD1060606 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM.

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生物&药学活性

DDD1060606 is a small molecule inhibitor of HsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM.

物理化学性质&存储条件

分子量	326.42
分子式	C17H18N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(1H-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl)-2-(thiophen-3-yl)ethan-1-one

参考文献

1. Pearson LA, et al. Biochem J. 2025 Jan 27:BCJ20240608.

DDD1060606

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物理化学性质&存储条件

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DDD1060606

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