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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-DDC4002
DDC4002

Chemical Structure : DDC4002

CAS No.: 2375048-04-5

DDC4002 (DDC 4002, DDC-4002 )

货号: PC-21851Not For Human Use, Lab Use Only.

DDC4002 is a potent, selective and allosteric EGFR inhibitor, shows selectivity against L858R/T790M/C797S EGFR mutants with IC50 of 39-50 nM, does not inhibit WT EGFR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DDC4002 is a potent, selective and allosteric EGFR inhibitor, shows selectivity against L858R/T790M/C797S EGFR mutants with IC50 of 39-50 nM, does not inhibit WT EGFR.

物理化学性质&存储条件

分子量 318.35
分子式 C20H15FN2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

参考文献

1. Maity S, et al. Pharmacol Rep. 2020 Aug;72(4):799-813.

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