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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -DCPIB
DCPIB

Chemical Structure : DCPIB

CAS No.: 82749-70-0

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DCPIB (SN-401, SN401)

货号: PC-72941Not For Human Use, Lab Use Only.

DCPIB (SN-401) is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), inhibits TRESK, TASK1 and TASK3 with IC50 of 0.14, 0.95, and 50.72 uM respectively.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DCPIB (SN-401) is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), inhibits TRESK, TASK1 and TASK3 with IC50 of 0.14, 0.95, and 50.72 uM respectively.
DCPIB (SN-401) is a SWELL1 channel inhibitor that bind the SWELL1-LRRC8 channel complexes (IC50=3.9 uM).
SN-401 increases adipocyte SWELL1 protein expression, and SWELL1-dependent insulin signaling.
SN-401 increases SWELL1 and improves systemic glucose homeostasis in murine T2D models by enhancing insulin sensitivity and secretion.
SN-401 improves systemic insulin sensitivity, tissue glucose uptake, and nonalcoholic fatty liver disease in murine T2D models.
SN-401 inhibits ICl,SWELL but promote SWELL1-dependent signaling at sub-micromolar concentrations (0.1-1 uM).
SN-401 prevents reductions in SWELL1 protein and rescues SWELL1-dependent islet insulin secretion under glucolipotoxic conditions.
SN-401 congeners improve glycemic control in murine T2D models

物理化学性质&存储条件

分子量 427.362
分子式 C22H28Cl2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((6,7-dichloro-2-cyclopentyl-1-oxo-2-pentyl-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid

参考文献

1. David M Kern, et al. Elife. 2019 Feb 18;8:e42636.

2. Gunasekar SK, et al. Nat Commun. 2022 Feb 10;13(1):784.

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