DCLK1-IN-1 | DCLK1 inhibitor | Probechem Biochemicals

Chemical Structure : DCLK1-IN-1

CAS No.: 2222635-15-4

加入收藏

DCLK1-IN-1 (DCLK1 inhibitor)

货号: PC-38227Not For Human Use, Lab Use Only.

DCLK1-IN-1 is the first potent, selective inhibitor of the DCLK1 and DCLK2 kinases with IC50 of 9.5 nM and 31 nM in binding assays, respectively.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DCLK1-IN-1 is the first potent, selective inhibitor of the DCLK1 and DCLK2 kinases with IC50 of 9.5 nM and 31 nM in binding assays, respectively.
DCLK1-IN-1 exclusively inhibited DCLK1 and DCLK2 across a panel of 489 human kinases, significantly inhibited DCLK1, and weakly inhibited ERK5, in PATU-8988T cell lysates and live cells, did not inhibit any kinases under these conditions.
DCLK1-IN-1 displays pronounced on-target DCLK1 activity in vitro, and is suitable probe for in vivo evaluation.
Proteins associated with cell motility, including HN1, ZIP8 and FYN, were significantly downregulated after DCLK1-IN-1 treatment in the organoid cultures.

物理化学性质&存储条件

分子量	527.552
分子式	C26H28F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5-(2,2,2-trifluoroethyl)-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

参考文献

1. Fleur M Ferguson, et al. Nat Chem Biol. 2020 Jun;16(6):635-643.

2. Fleur M Ferguson, et al. J Med Chem. 2020 Jul 23;63(14):7817-7826.

DCLK1-IN-1 (DCLK1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DCLK1-IN-1 (DCLK1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.