DCDBS84 hydrobromide

Chemical Structure : DCDBS84 hydrobromide

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货号: PC-25816Not For Human Use, Lab Use Only.

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生物&药学活性

DCDBS84 hydrobromide is a small molecule specifically targeting c‐Src SH3 RT‐loop with SPR Kd of 0.83 uM, disrupts the interaction of integrin β3 with Src SH3, selectively blocks αIIbβ3 outside‐in signaling and shows potent antithrombotic effect.
DCDBS84 does not affect the tyrosine kinase activity of Src.
DCDBS84 disrupts the interaction of integrin β3 with Src SH3, affecting the phosphorylation of β3 and Src, without affecting canonical PXXP binding.
DCDBS84 selectively inhibits platelet functions mediated by outside‐in signaling.
DCDBS84 effectively suppresses occlusive thrombus formation without affecting bleeding time in mice.
DCDBS84 has potent antithrombotic effect without compromising primary hemostasis by selectively blocking outside‐in signaling through integrin αIIbβ3.

物理化学性质&存储条件

分子量	509.21
分子式	C16H19Br2N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 5-acetoxy-6-bromo-2-((carbamimidoylthio)methyl)-1-methyl-1H-indole-3-carboxylate hydrobromide

参考文献

1. Mao J, et al. Adv Sci (Weinh). 2022 Mar;9(7):e2103228.