DCC-2618 | KIT inhibitor | Probechem Biochemicals

Chemical Structure : DCC-2618

CAS No.: 1442472-39-0

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DCC-2618 (Ripretinib, DCC2618)

货号: PC-62101Not For Human Use, Lab Use Only.

DCC-2618 (Ripretinib) is a potent, oral inhibitor of singly and doubly mutated KIT with IC50 of WT (IC50=4 nM), V654A (8 nM), T670I (18 nM), D816H (5 nM), D816V.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2280	In stock
25 mg	￥3880	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

DCC-2618 (Ripretinib, DCC2618) is a potent, oral inhibitor of singly and doubly mutated KIT with IC50 of WT (IC50=4 nM), V654A (8 nM), T670I (18 nM), D816H (5 nM), D816V.
DCC-2618 also inhibits PDGFRα/β, KDR and cFMS, robustly inhibits exon 17, exon 9/13, exon 9/14, and exon 9/17 KIT mutants, as well as exon 11/17 KIT mutants.
DCC-2618 inhibits wild type and mutant KIT phosphorylation in cancer cells, demonstrates the potential to treat KIT mutant-driven cancers including GIST, systemic mastocytosis, AML, or melanoma.

物理化学性质&存储条件

分子量	510.367
分子式	C24H21BrFN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

参考文献

1. Mathias A Schneeweiss, et al. Blood 2016 128:1965.

2. Cancer Discov. 2017 Feb;7(2):121-122. doi: 10.1158/2159-8290.

DCC-2618 (Ripretinib, DCC2618)

生物&药学活性

物理化学性质&存储条件

参考文献

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DCC-2618 (Ripretinib, DCC2618)

生物&药学活性

物理化学性质&存储条件

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