DC2-C1

Chemical Structure : DC2-C1

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货号: PC-25924Not For Human Use, Lab Use Only.

DC2-C1 is a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2 with IC50 of 168 nM in FP assays, high selectivity over other YTH-domain proteins.

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生物&药学活性

DC2-C1 is a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2 with IC50 of 168 nM in FP assays, high selectivity over other YTH-domain proteins.
DC2-C1 exhibits a robust binding affinity with an equilibrium dissociation constant (KD) of 0.46 uM in ITC assays.
DC2-C1 markedly reduced YTHDC2-AMIGO2 mRNA binding in MH7A cells, substantially accelerated AMIGO2 mRNA degradation, substantially inhibited MH7A cell clonogenic potential.
DC2-C1 markedly suppressed the clonogenic potential and invasion in PANC-1 or MiaPACA-2 cells.
DC2-C1 induced a dose-dependent increase in ACC1, FASN, and SREBP-1C mRNA levels in HepG2 cells, with no effect on FZD7 and ID2 mRNA, which are targets of YTHDF1 and YTHDF2, respectively.

物理化学性质&存储条件

分子量	472.72
分子式	C22H15BrClNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-bromo-3-chloro-2-hydroxyphenyl)-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

参考文献

1. Yang Z, et al. Nat Commun. 2026 Jan 6;17(1):46.

DC2-C1

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物理化学性质&存储条件

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DC2-C1

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