DC-U4106 | USP8 inhibitor | Probechem Biochemicals

Chemical Structure : DC-U4106

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DC-U4106 (DC-U 4106)

货号: PC-49051Not For Human Use, Lab Use Only.

DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7.

规格	价格	库存	数量
10 mg		Get quote
25 mg		Get quote
50 mg		Get quote

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生物&药学活性

DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7.
DC-U4106 could target the ubiquitin pathway and facilitate the degradation of Erα inwestern blotting and immunoprecipitation assays.
DC-U4106 also significantly inhibited tumor growth with minimal toxicity in a xenograft tumor model.
DC-U4106 is a promising drug candidate and targeting the USP8-ERα complex for treat ER-positive or drug-resistant breast cancer.

物理化学性质&存储条件

分子量	525.565
分子式	C29H27N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((3,5-dimethyl-1H-pyrazol-4-yl)oxy)-5,7-dihydroxy-2-(4-(4-(pyridin-2-yl)piperazin-1-yl)phenyl)-4H-chromen-4-one

参考文献

1. Yucheng Tian, et al. J Med Chem. 2022 Jul 5. doi: 10.1021/acs.jmedchem.2c00013.

DC-U4106 (DC-U 4106)

生物&药学活性

物理化学性质&存储条件

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DC-U4106 (DC-U 4106)

生物&药学活性

物理化学性质&存储条件

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