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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-DC-TEADin1072
DC-TEADin1072

Chemical Structure : DC-TEADin1072

CAS No.: 1574602-93-9

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DC-TEADin1072 (TEAD1/TEAD3 inhibitor)

货号: PC-73282Not For Human Use, Lab Use Only.

DC-TEADin1072 is a novel TEAD1/3 covalent inhibitor with biochemical IC50 values of 0.61 and 0.58 uM against TEAD1 and TEAD3, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DC-TEADin1072 is a novel TEAD1/3 covalent inhibitor with biochemical IC50 values of 0.61 and 0.58 uM against TEAD1 and TEAD3, respectively.
    TEADin1072 selectively inhibited TEAD1 and TEAD3 palmitoylation while sparing TEAD2 and TEAD4.
    TEADin1072 demonstrated selective engagement with Cys371 of TEAD3 and Cys359 of TEAD1.

    物理化学性质&存储条件

    分子量 259.349
    分子式 C16H21NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-(2-phenoxyethyl)piperidin-1-yl)prop-2-en-1-one

    参考文献

    1. Tian Lu, et al. Acta Pharm Sin B. 2021 Oct;11(10):3206-3219.

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