DC-LC3in-D5

Chemical Structure : DC-LC3in-D5

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货号: PC-72653Not For Human Use, Lab Use Only.

DC-LC3in-D5 is a small molecule covalent modulator of LC3A/B and autophagy inhibitor, binds to LC3B and covalently modifies Lysine 49.

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生物&药学活性

DC-LC3in-D5 is a small molecule covalent modulator of LC3A/B and autophagy inhibitor, binds to LC3B and covalently modifies Lysine 49.
DC-LC3in-D5 selectively reacts with LC3A/B in vitro (IC50=200 nM, FP assays)
DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells, disrupts the ATG7-LC3B interaction and blocks LC3B lipidation.
DC-LC3in-D5 compromises LC3B lipidation in vitro and in HeLa cells, leading to deficiency in the formation of autophagic structures and autophagic substrate degradation.
DC-LC3in-D5 is a powerful tool for autophagy research with little cellular toxicity.
The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein–protein interaction (PPI) target for the intervention of autophagy.

物理化学性质&存储条件

分子量	397.296
分子式	C19H22Cl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2,3-dichlorophenyl)-2-(((2-morpholinoethyl)amino)methylene)cyclohexane-1,3-dione

参考文献

1. Shijie Fan, et al. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114.

DC-LC3in-D5

生物&药学活性

物理化学性质&存储条件

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DC-LC3in-D5

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