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首页-小分子抑制剂&激动剂-Others-Other Targets-DC-5163
DC-5163

Chemical Structure : DC-5163

CAS No.: 897771-47-0

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DC-5163 (DC5163)

货号: PC-22460Not For Human Use, Lab Use Only.

DC-5163 is a smal molecule glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with IC50 of 176.3 nM, inhibits glucose uptake, reduces lactic acid production, selectively inhibits cancer cell proliferation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DC-5163 is a smal molecule glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with IC50 of 176.3 nM, inhibits glucose uptake, reduces lactic acid production, selectively inhibits cancer cell proliferation.
DC-5163 interacts with GAPDH protein with KD of 3.192 uM in microscale thermophoresis assays.
DC-5163 inhibits MDA-MB-231 cell proliferation with an IC50 of 99.22 μM at 48 h and 52.09 μM at 72 h, induces apoptosis and suppressed glycolysis.

物理化学性质&存储条件

分子量 361.89
分子式 C18H20ClN3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-benzyl-N-(3-chloro-4-methoxyphenyl)imidazolidine-1-carbothioamide

参考文献

1. Li T, et al. Bioorg Chem. 2020 Mar;96:103620.

2. Zhang YQ, et al. Cancer Cell Int. 2024 May 29;24(1):188.

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