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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-DC-174
DC-174

Chemical Structure : DC-174

CAS No.:

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DC-174 (DC174)

货号: PC-26511Not For Human Use, Lab Use Only.

DC-174 is a potent broad-spectrum snake venom metalloproteinases (SVMPs) inhibitor with enzymetic EC50 of 4.7 nM for ERO (E. romani) SVMP.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DC-174 is a potent broad-spectrum snake venom metalloproteinases (SVMPs) inhibitor with enzymetic EC50 of 4.7 nM for ERO (E. romani) SVMP.
DC-174 shows broad-spectrum potent inhibition of SVMP activity (4.7–38.6 nM EC50s), inhibition of procoagulant venom activity (13.4 and 135.0 nM EC50s in B. jararaca and E. romani, respectively).
DC-174 reduces SVMP isoform-mediated cleavage of clotting factors and venom-induced coagulopathy and protects against lethality and hemorrhage in a chicken embryo model of envenoming.
DC-174 prolongs survival in a murine preclinical model of severe envenoming.

物理化学性质&存储条件

分子量 419.47
分子式 C15H21N3O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-(Cyclopropylsulfonyl)-N-hydroxy-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide

参考文献

1. Chong DJW, et al. J Med Chem. 2026 Apr 9. doi: 10.1021/acs.jmedchem.6c00064.

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