DBPR728 | Aurora A inhibitor | Probechem Biochemicals

Chemical Structure : DBPR728

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DBPR728 (DBPR-728)

货号: PC-22141Not For Human Use, Lab Use Only.

DBPR728 is an oral bioavailable acyl-based prodrug of 6K465, which is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

DBPR728 is an oral bioavailable acyl-based prodrug of 6K465, which is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.
DBPR728 induced durable tumor regression of c-MYC- and/or N-MYC- overexpressing xenografts including SCLC, triple-negative breast cancer (TNBC), hepatocellular carcinoma and medulloblastoma.
DBPR728 at 300 mg/kg induced c-MYC reduction and cell apoptosis in the tumor xenografts for more than 7 days.
DBPR728 also synergized with the mTOR inhibitor everolimus to suppress c-MYC- or N-MYC- driven SCLC.

物理化学性质&存储条件

分子量	598.12
分子式	C29H37ClFN9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-((2-((1-(3-chloro-2-fluorobenzoyl)piperidin-4-yl)amino)-6-(4-ethylpiperazin-1-yl)pyrimidin-4-yl)amino)-3-methyl-1H-pyrazol-1-yl)propan-1-one

参考文献

1. Chang CP, et al. Mol Cancer Ther. 2024 Apr 9. doi: 10.1158/1535-7163.MCT-23-0602.

DBPR728 (DBPR-728)

生物&药学活性

物理化学性质&存储条件

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DBPR728 (DBPR-728)

生物&药学活性

物理化学性质&存储条件

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