Gozanertinib (DBPR112) | EGFR mutant inhibitor | Probechem Biochemicals

Chemical Structure : DBPR112

CAS No.: 1226549-49-0

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DBPR112 (Gozanertinib, DBPR 112)

货号: PC-73088Not For Human Use, Lab Use Only.

Gozanertinib (DBPR112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations.

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生物&药学活性

Gozanertinib (DBPR112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations.
DBPR112 inhibited HCC827 cell growth with IC50 of 25 nM, exhibited tenfold potency better than the third-generation inhibitor, osimertinib, against EGFR and HER2 exon 20 insertion mutations.
DBPR112 demonstrated significant antitumor efficacy in in vivo xenograft models.

物理化学性质&存储条件

分子量	533.632
分子式	C32H31N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-4-(dimethylamino)-N-(3-(4-((2-hydroxy-1-phenylethyl)amino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide

参考文献

1. Shu-Yu Lin, et al. J Med Chem. 2019 Nov 27;62(22):10108-10123.

DBPR112 (Gozanertinib, DBPR 112)

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DBPR112 (Gozanertinib, DBPR 112)

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物理化学性质&存储条件

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