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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Dipeptidyl Peptidase (DPP)-DBPR108
DBPR108

Chemical Structure : DBPR108

CAS No.: 1186426-66-3

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DBPR108 (Prusogliptin, DBPR-108)

货号: PC-43097Not For Human Use, Lab Use Only.

Prusogliptin (DBPR108) is a potent, selective, orally bioavailable and long-acting inhibitor of DPP4 with IC50 of 15 nM, >3,000-fold selectivity over DPP8, DPP9, FAP and DPP-II.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Prusogliptin (DBPR108) is a potent, selective, orally bioavailable and long-acting inhibitor of DPP4 with IC50 of 15 nM, >3,000-fold selectivity over DPP8, DPP9, FAP and DPP-II.
Prusogliptin (DBPR108) exhibits excellent human plasma DPP-IV inhibition with IC50 of 5 nM.
Prusogliptin (DBPR108) suppresses blood glucose elevation in vivo, demonstrates potential treatment of type 2 diabetes mellitus.

物理化学性质&存储条件

分子量 324.3937
分子式 C16H25FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyrrolidinecarbonitrile, 1-[2-[[1,1-dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl]amino]acetyl]-4-fluoro-, (2S,4S)-

参考文献

1. Yeh TK, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600.

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