SMAP-2 |CAS:1809068-70-9 Probechem Biochemicals

Chemical Structure : DBK-1154

CAS No.: 1809068-70-9

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DBK-1154 (SMAP-2, DT-1154, DBK1154)

货号: PC-62749Not For Human Use, Lab Use Only.

SMAP-2 (DT-1154, DBK1154) is an orally bioavailable small molecule activator of PP2A, binds to PP2A Aα scaffold subunit and inhibits KRAS-driven tumor growth both in vitro and in vivo.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SMAP-2 (DT-1154, DBK1154) is an orally bioavailable small molecule activator of PP2A, binds to PP2A Aα scaffold subunit and inhibits KRAS-driven tumor growth both in vitro and in vivo.
SMAP-2 (DT-1154, DBK1154) decreases cellular viability and clonogenicity and induces apoptosis in castrate-resistant prostate cancer (CRPC) cells.
SMAP-2 (DT-1154, DBK1154) significantly changes the phosphoproteome, including dephosphorylation of full-length and truncated isoforms of the AR and downregulation of its regulatory kinases.
SMAP-2 (DT-1154, DBK1154) exhibits efficacy comparable to enzalutamide in vivo.

物理化学性质&存储条件

分子量	532.578
分子式	C27H27F3N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1S,2S,3R)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-2-hydroxycyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide

参考文献

1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090.

2. McClinch K, et al. Cancer Res. 2018 Jan 22. pii: canres.0123.2017.

DBK-1154 (SMAP-2, DT-1154, DBK1154)

生物&药学活性

物理化学性质&存储条件

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DBK-1154 (SMAP-2, DT-1154, DBK1154)

生物&药学活性

物理化学性质&存储条件

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