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首页-小分子抑制剂&激动剂-Others-Other Targets-DB1055
DB1055

Chemical Structure : DB1055

CAS No.: 869767-86-2

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DB1055 (DB-1055, DB 1055)

货号: PC-36000Not For Human Use, Lab Use Only.

DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.
    DB1055 directly binds to HOXA9-cognate sequence with Kd value of 5.5 nM (HBS sequence).
    DB1055 alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line.

    物理化学性质&存储条件

    分子量 354.417
    分子式 C21H18N6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3'-carbamimidoyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d]imidazole-6-carboximidamide

    参考文献

    1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448.

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