DB04760 |CAS:544678-85-5 Probechem Biochemicals

Chemical Structure : DB04760

CAS No.: 544678-85-5

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DB04760 (DB 04760, DB-04760)

货号: PC-62941Not For Human Use, Lab Use Only.

DB04760 is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs.

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5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

DB04760 is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs.
DB04760 does not interact with the catalytic zinc but bind deeply in the S1' pocket of MMP-13.
DB04760 significantly rescues axon regeneration and axon debris clearance, greatly reduces neurotoxicity associated with paclitaxel treatment in larval and adult zebrafish.

物理化学性质&存储条件

分子量	410.425
分子式	C22H20F2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide

参考文献

1. Engel CK, et al. Chem Biol. 2005 Feb;12(2):181-9.

2. Lisse TS, et al. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2189-98.

3. Waldron AL, et al. J Diabetes Complications. 2018 Mar;32(3):249-257.

DB04760 (DB 04760, DB-04760)

生物&药学活性

物理化学性质&存储条件

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DB04760 (DB 04760, DB-04760)

生物&药学活性

物理化学性质&存储条件

参考文献

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