DAPT |CAS:208255-80-5 Probechem Biochemicals

Chemical Structure : DAPT

CAS No.: 208255-80-5

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DAPT (GSI-IX;GSI IX)

货号: PC-43337Not For Human Use, Lab Use Only.

DAPT (GSI-IX, GSI IX) is a small molecule γ-secretase inhibitor that reduces the total beta-amyloid peptide (Aβ) production with IC50 of 20 nM in HEK 293 cells, without affecting protein secretion.

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10 mg	￥880	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
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生物&药学活性

DAPT (GSI-IX, GSI IX) is a small molecule γ-secretase inhibitor that reduces the total beta-amyloid peptide (Aβ) production with IC50 of 20 nM in HEK 293 cells, without affecting protein secretion.
DAPT (GSI-IX, GSI IX) decreases the Notch intracellular domain and inhibition of Notch signaling, down-regulates P-glycoprotein and ERCC1 protein in CNE-2 cells.
DAPT (GSI-IX, GSI IX) reduces brain levels of beta-amyloid peptide in brain.
DAPT (GSI-IX, GSI IX) protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and NF-κB in rats.

物理化学性质&存储条件

分子量	432.4604
分子式	C23H26F2N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 215 mg/mL
Chemical Name/SMILES	Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

参考文献

1. Dovey HF, et al. J Neurochem. 2001 Jan;76(1):173-81.

2. Li S, et al. Neurol Sci. 2012 Dec;33(6):1257-64.

3. Zhou JX, et al. Exp Ther Med. 2012 Feb;3(2):357-361.

DAPT (GSI-IX;GSI IX)

生物&药学活性

物理化学性质&存储条件

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DAPT (GSI-IX;GSI IX)

生物&药学活性

物理化学性质&存储条件

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