DALTAC-1 | AR-p300/CBP DALTAC | Probechem Biochemicals

Chemical Structure : DALTAC-1

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DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1)

货号: PC-26742Not For Human Use, Lab Use Only.

DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1) is a specific AR-p300/CBP Domain-ALTeration Chimeras (DALTAC), targets the AR-p300 complex by repurposing their natural interfaces to block activation of the AR oncogenic enhanceosome, selectively suppresses the growth of AR-positive prostate cancer cells.

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生物&药学活性

DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1) is a specific AR-p300/CBP Domain-ALTeration Chimera (DALTAC), targets the AR-p300 complex by repurposing their natural interfaces to block activation of the AR oncogenic enhanceosome, selectively suppresses the growth of AR-positive prostate cancer cells.
DALTAC-1 induces AR and p300 proteins into proximity to form a stable ternary complex.
DALTAC-1-induced proximity of AR and p300 proteins inhibits their oncogenic transcriptional output in AR-positive prostate cancer cells.
DALTAC-1 selectively reprograms the acetylome in AR-positive prostate cancer cells.
DALTAC-1 potently suppresses the growth of prostate cancer organoids, exhibits potent in vivo efficacy against prostate cancer.
DALTAC-1 effectively redirects AR-p300 interactions, inhibiting p300 binding to the AR-NTD while enhancing its interaction with the AR-LBD.

物理化学性质&存储条件

分子量	974.60
分子式	C52H62ClF2N13O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-(((1r,4r)-4-(5-acetyl-3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)methyl)piperazin-1-yl)-N-((1r,4r)-4-((3-chloro-4-cyanophenyl)(methyl)amino)cyclohexyl)pyridazine-3-carboxamide

参考文献

1. Luo J, et al. bioRxiv [Preprint]. 2026 Apr 28:2026.04.24.720638.

DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1)

生物&药学活性

物理化学性质&存储条件

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DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1)

生物&药学活性

物理化学性质&存储条件

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