DAGL inhibitor DO34 | DAGLα/β inhibitor | Probechem Biochemicals

Chemical Structure : DAGL inhibitor DO34

CAS No.: 1848233-58-8

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DAGL inhibitor DO34 (DO34)

货号: PC-61837Not For Human Use, Lab Use Only.

DAGL inhibitor DO34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
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100 mg		Get quote

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生物&药学活性

DAGL inhibitor DO34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively.
DO34 shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 and PLA2G7.
DO34 significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model.

物理化学性质&存储条件

分子量	531.53
分子式	C26H28F3N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl 3-benzyl-4-(4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carbonyl)piperazine-1-carboxylate

参考文献

1. Ogasawara D, et al. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.

2. Deng H, et al. J Med Chem. 2017 Jan 12;60(1):428-440.

3. Wilkerson JL, et al. J Pharmacol Exp Ther. 2017 Oct 2. pii: jpet.117.243808.

DAGL inhibitor DO34 (DO34)

生物&药学活性

物理化学性质&存储条件

参考文献

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DAGL inhibitor DO34 (DO34)

生物&药学活性

物理化学性质&存储条件

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