DAC-003 | HDAC1 activator | Probechem Biochemicals

Chemical Structure : DAC-003

加入收藏

DAC-003 (Deacetylase-activating compound)

货号: PC-25165Not For Human Use, Lab Use Only.

DAC-003 is a small molecule activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, DAC-003 is protective against oxidative stress.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DAC-003 is a small molecule activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, DAC-003 is protective against oxidative stress.
DAC-003 (10 uM) maintains deacetylation of key histones (H3K56, H4K12, H3K14) after 20 h in HEK293T cells, induces functional HDAC1 activation and prevention of Ac-H4K12 accumulation.
DAC-003 displays significant protection against DNA breaks.

物理化学性质&存储条件

分子量	334.34
分子式	C17H14N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((2-(6-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)hydrazineylidene)methyl)benzene-1,2-diol

参考文献

1. L.-H. Tsai, S.J. et al. Activators of Class i Histone Deacetlyases (Hdacs) and Uses Thereof (2013). WO 2013/016193 A2.

DAC-003 (Deacetylase-activating compound)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DAC-003 (Deacetylase-activating compound)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.