D715-2441 | Influenza PB2 inhibitor | Probechem Biochemicals

Chemical Structure : D715-2441

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D715-2441 (D 715-2441)

货号: PC-35605Not For Human Use, Lab Use Only.

D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM.

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生物&药学活性

D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM.
D715-2441 does not inhibit both viral entry and release, disrupts early influenza A virus replication, reduces vRNP activity and affects PB2 protein localization.
D715-2441 shows binding affinity to influenza PB2cap protein with Kd of 0.118 uM.
D715-2441 demonstrates a remarkable synergistic antiviral effect (FICI value of 0.40) combined with zanamivir.

物理化学性质&存储条件

分子量	228.203
分子式	C13H8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-dihydroxy-6H-benzo[c]chromen-6-one

参考文献

1. Liu T, et al. Mol Pharm. 2018 Aug 23. doi: 10.1021/acs.molpharmaceut.8b00531.

D715-2441 (D 715-2441)

生物&药学活性

物理化学性质&存储条件

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D715-2441 (D 715-2441)

生物&药学活性

物理化学性质&存储条件

参考文献

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