D66 | Antibacterial | Probechem Biochemicals

Chemical Structure : D66

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D66 (S. Typhimurium inhibitor)

货号: PC-47041Not For Human Use, Lab Use Only.

D66 is a specific small molecule that disrupts S. Typhimurium membrane voltage without cell lysis, prevents S. Typhimurium survival in macrophages (IC50=6.0 uM) and inhibits bacterial growth under conditions that compromise the cell envelope.

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生物&药学活性

D66 is a specific small molecule that disrupts S. Typhimurium membrane voltage without cell lysis, prevents S. Typhimurium survival in macrophages (IC50=6.0 uM) and inhibits bacterial growth under conditions that compromise the cell envelope.
D66 rapidly perturbs the bacterial cytoplasmic membrane with minor disruption of barrier function.
D66 disrupts voltage across the bacterial inner membrane at concentrations that do not permeabilize the inner membrane or lyse cells.
D66 does not permeabilize the mammalian cell membrane but does cause stress, as revealed by hyperpolarization of mitochondrial membranes.

物理化学性质&存储条件

分子量	378.297
分子式	C19H21Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-benzyl-N-(3,5-dichlorophenyl)-1,4-diazepane-1-carboxamide

参考文献

1. Jamie L Dombach, et al. PLoS Pathog. 2022 Jun 10;18(6):e1010606.

D66 (S. Typhimurium inhibitor)

生物&药学活性

物理化学性质&存储条件

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D66 (S. Typhimurium inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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