D347-2761

Chemical Structure : D347-2761

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货号: PC-23434Not For Human Use, Lab Use Only.

D347-2761 is a small molecule c-Myc inhibitor, blocks c-Myc/Max heterodimer and disturbs c-Myc protein stability simultaneously, inhibits c-Myc-mediated transcriptional activities.

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生物&药学活性

D347-2761 is a small molecule c-Myc inhibitor, blocks c-Myc/Max heterodimer and disturbs c-Myc protein stability simultaneously, inhibits c-Myc-mediated transcriptional activities.
D347-2761 dose-and time-dependently inhibited RPMI-8226 and NCI-H929 cell viabilities significantly, but not normal PBMCs.
D347-2761 synergized with bortezomib to promote DNA damage in RPMI-8226 and NCI-H929 cells.
D347-2761 overcame BTZ drug resistance in MM cells.
D347-2761 inhibited primary tumor growth in humanized myeloma xenograft mouse model.
D347-2761 disturbed c-Myc stability to regulate downstream target genes, inhibited the expression of ACAT1, CDK4, NME1, PIM3, and SMYD2 at the mRNA levels in RPMI-8226 cells.

物理化学性质&存储条件

分子量	439.56
分子式	C28H29N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(2-(3,5-dimethylphenoxy)ethyl)-1H-benzo[d]imidazol-2-yl)-1-(m-tolyl)pyrrolidin-2-one

参考文献

1. Yao R, et al. Cell Commun Signal. 2022 May 26;20(1):73.

2. Gao J, et al. Eur J Med Chem. 2024 Nov 7;281:117023.

D347-2761

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物理化学性质&存储条件

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D347-2761

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物理化学性质&存储条件

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