D2AAK1

Chemical Structure : D2AAK1

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货号: PC-27970Not For Human Use, Lab Use Only.

D2AAK1 is a high-affinity dopamine D2 receptor antagonist with Ki of 58 nM, also possesses additional nanomolar or low micromolar affinity to D1, D3, 5-HT1A and 5-HT2A receptors, shows antipsychotic activity in vivo.

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生物&药学活性

D2AAK1 is a high-affinity dopamine D2 receptor antagonist with Ki of 58 nM, also possesses additional nanomolar or low micromolar affinity to D1, D3, 5-HT1A and 5-HT2A receptors, shows antipsychotic activity in vivo.

物理化学性质&存储条件

分子量	385.47
分子式	C24H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(5-methoxy-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl)methyl)quinolin-2(1H)-one

参考文献

1. Kaczor AA, et al. Neurochem Int. 2016 Jun;96:84-99.

2. Koszła O, et al. Int J Mol Sci. 2020 Nov 23;21(22):8849.

D2AAK1

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D2AAK1

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