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首页-抗体药物偶连体和PROTACs-ADC Cytotoxin-D211
D211

Chemical Structure : D211

CAS No.: 1971075-99-6

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D211 ((S,S)-D211;D-211)

货号: PC-60140Not For Human Use, Lab Use Only.

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.

物理化学性质&存储条件

分子量 656.739
分子式 C39H36N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6aS,6a'S)-3,3'-(propane-1,3-diylbis(oxy))bis(2-methoxy-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinolin-14(6aH)-one)

参考文献

1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436

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